COMPUTER APPLICATIONS IN NUCLEIC ACID CHEMISTRY
نویسندگان
چکیده
منابع مشابه
Nucleic acid chemistry
Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick [1], we know that DNA is of critical importance, carrying the genetic information for all living organisms. Only a few years later appeared the first reports on the chemical synthesis of oligonucleotides with a natural 3'-5' phosphodiester linker by Michelsen and Todd [2]. It took another two decades until ...
متن کاملEarly nucleic acid chemistry.
,g i:. The contemporary biochemist, perusing the publications of the past century, may easily be misled into some arrogance when sorting out the erroneous data and leads, the slow progress and the primitive reports of that early period. However, when recalling the limited techniques and the lack of facilities at the early stages of biochemistry, he will change his mind. The difficulties encount...
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The increasing body of nucleic acid sequence data has created interest among many scientists in computational aspects of data storage and data processing. In fact GenBank and other data bases hade been created in order to store the data in a useful format, both for archival and analysis purposes. (See Burks et a/.' for a review of GenBank activities.) The value of simply have easy a m e s to al...
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Under the appropriate experimental conditions of pH and temperature, cytosine-rich segments in DNA or RNA sequences may produce a characteristic folded structure known as an i-motif. Besides its potential role in vivo, which is still under investigation, this structure has attracted increasing interest in other fields due to its sharp, fast and reversible pH-driven conformational changes. This ...
متن کاملLanthanide Chelates as a Tool in Nucleic Acid Chemistry
The potentiality of lanthanide chelates as photoluminescent markers and cleaving agents of nucleic acids is discussed, the main emphasis being on the chelates derived from aromatic nitrogen bases.
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ژورنال
عنوان ژورنال: World Journal of Pharmaceutical Research
سال: 2017
ISSN: 2277-7105
DOI: 10.20959/wjpr20176-8590